%0 Journal Article
%T Anti-annexin V Antibodies in Women with Recurrent Miscarriage
%A M.N. EL-Gharib
%A T.M. Elhawary
%A S.H. Elshourbagy and M.A. Morad
%J Clinical Medicine Insights: Reproductive Health
%D 2012
%I 
%R 10.4137/CMRH.S5835
%X Objective: To determine the role of anti-annexin V antibodies (a-A5) as an etiologic factor in recurrent pregnancy failure. Study design: Prospective observational study. Material and methods: The study included ninety first trimester pregnant women who had a history of unexplained recurrent miscarriage (group I) with ninety well-matched pregnant women with a history of normal reproductive outcome allocated as control group (GII) and another ninety nonpregnant women (GIII). Sera from all women controls were analyzed for anti-annexin antibody measured by Elisa. Results: The mean value of a-A5 was 11.37 ¡À 6.78, 7.7 ¡À 1.40 and 6.20 ¡À 0.95 ng/ml in groups I, II and III respectively. There was a significant increase in the mean value a-A5 among women with a history of recurrent miscarriage, compared with controls. The mean value was 13.92 ¡À 2.42 ng/ml among patients with unfavourable outcome, compared with a corresponding value of 6.95 V 0.58 ng/ml among women with favourable outcome. The receiver operator characteristic curve revealed that the cutoff value of a-A5 was 8.61 ng/ml. Conclusion: This study emphasizes the relationship between anti-annexin V antibodies and recurrent miscarriage.
%U http://www.la-press.com/anti-annexin-v-antibodies-in-women-with-recurrent-miscarriage-article-a2281