%0 Journal Article
%T Newton, Laplace, and The Epistemology of Systems Biology
%A Michael L. Bittner and Edward R. Dougherty
%J Cancer Informatics
%D 2012
%I 
%R 10.4137/CIN.S10630
%X For science, theoretical or applied, to significantly advance, researchers must use the most appropriate mathematical methods. A century and a half elapsed between Newton¡¯s development of the calculus and Laplace¡¯s development of celestial mechanics. One cannot imagine the latter without the former. Today, more than three-quarters of a century has elapsed since the birth of stochastic systems theory. This article provides a perspective on the utilization of systems theory as the proper vehicle for the development of systems biology and its application to complex regulatory diseases such as cancer.
%U http://www.la-press.com/newton-laplace-and-the-epistemology-of-systems-biology-article-a3394