%0 Journal Article
%T Role of Shwachman-Bodian-Diamond syndrome protein in translation machinery and cell chemotaxis: a comparative genomics approach
%A Vasieva O
%J Advances and Applications in Bioinformatics and Chemistry
%D 2011
%I Dove Medical Press
%R http://dx.doi.org/10.2147/AABC.S23510
%X le of Shwachman-Bodian-Diamond syndrome protein in translation machinery and cell chemotaxis: a comparative genomics approach Original Research (3414) Total Article Views Authors: Vasieva O Published Date September 2011 Volume 2011:4 Pages 43 - 50 DOI: http://dx.doi.org/10.2147/AABC.S23510 Olga Vasieva Institute of Integrative Biology, University of Liverpool, Liverpool, United Kingdom; Fellowship for the Interpretation of Genomes, Burr Ridge, IL, USA Abstract: Shwachman-Bodian-Diamond syndrome (SBDS) is linked to a mutation in a single gene. The SBDS proinvolved in RNA metabolism and ribosome-associated functions, but SBDS mutation is primarily linked to a defect in polymorphonuclear leukocytes unable to orient correctly in a spatial gradient of chemoattractants. Results of data mining and comparative genomic approaches undertaken in this study suggest that SBDS protein is also linked to tRNA metabolism and translation initiation. Analysis of crosstalk between translation machinery and cytoskeletal dynamics provides new insights into the cellular chemotactic defects caused by SBDS protein malfunction. The proposed functional interactions provide a new approach to exploit potential targets in the treatment and monitoring of this disease.
%K Shwachman-Bodian-Diamond syndrome
%K wybutosine
%K tRNA
%K chemotaxis
%K translation
%K genomics
%K gene proximity
%U https://www.dovepress.com/role-of-shwachman-bodian-diamond-syndrome-protein-in-translation-machi-peer-reviewed-article-AABC