%0 Journal Article
%T Interaction between glucocorticoids and opioids in nociception in young and adult rats
%A Mahnaz Kesmati
%A Maryem Rezaie
%A Hadi Fathi-Moghaddam
%J Open Access Animal Physiology
%D 2010
%I 
%R http://dx.doi.org/10.2147/OAAP.S10007
%X teraction between glucocorticoids and opioids in nociception in young and adult rats Original Research (2925) Total Article Views Authors: Mahnaz Kesmati, Maryem Rezaie, Hadi Fathi-Moghaddam Published Date November 2010 Volume 2010:2 Pages 87 - 92 DOI: http://dx.doi.org/10.2147/OAAP.S10007 Mahnaz Kesmati1, Maryem Rezaie1, Hadi Fathi-Moghaddam2 1Department of Biology, Faculty of Sciences, Shahid Chamran University, Ahvaz; 2Department of Physiology and Persian Gulf Physiology Research Center, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Background: The aim of this study was to examine the relationship between the glucocorticoid and opioid systems in the modulation of nociception in young and adult rats. Materials and methods: The experiments were done in young and adult Wistar rats, using morphine 5 mg/kg, and naloxone 2 mg/kg as a ¦Ì-opioid receptor agonist. Dexamethasone 1 mg/kg and mifepristone (RU486) 20 mg/kg were used as a glucocorticoid receptor agonist and antagonist, respectively. Hind paw licking latency was measured by hot plate after intraperitoneal administration of drugs. Results: The results showed that morphine and dexamethasone had significant analgesic effects (P < 0.001, P < 0.01, respectively) in both age groups. Coadministration of morphine and dexamethasone did not induce a greater analgesic effect in comparison with morphine alone in either age group. Mifepristone prevented the analgesic effect of morphine in the adult animals (P < 0.001), but had no effect in young animals. The analgesic effect of dexamethasone was inhibited by naloxone in both groups (P < 0.01). Conclusion: These results suggest that glucocorticoids regulate opioid-induced analgesia from the age of puberty, but opioids regulate glucocorticoid-induced analgesia in prepubescent animals. Thus, there is a clear overlapping effect between the two pain modulation systems.
%K opioid
%K glucocorticoid
%K naloxone
%K mifepristone
%K hot plate
%U https://www.dovepress.com/interaction-between-glucocorticoids-and-opioids-in-nociception-in-youn-peer-reviewed-article-OAAP