%0 Journal Article
%T Molecular docking studies on the activity of naturally occurring pyranochalcones on the transcriptional regulator enzyme of Pseudomonas putida
%A Satya B Paul
%A Sudip Choudhury
%J Open Access Bioinformatics
%D 2010
%I 
%R http://dx.doi.org/10.2147/OAB.S10901
%X lecular docking studies on the activity of naturally occurring pyranochalcones on the transcriptional regulator enzyme of Pseudomonas putida Original Research (5549) Total Article Views Authors: Satya B Paul, Sudip Choudhury Published Date June 2010 Volume 2010:2 Pages 61 - 66 DOI: http://dx.doi.org/10.2147/OAB.S10901 Satya B Paul1, Sudip Choudhury2 1Department of Chemistry, Assam University, Silchar-788011, Assam, India; 2Department of Chemistry, Gurucharan College, Silchar-788004, Assam, India Abstract: The paper reports the in-silico docking results of 10 naturally occurring pyranochalcones on the transcriptional regulator (TtgR) enzyme, which is a key efflux pump TtgABC operon repressor in the Gram-negative bacteria Pseudomonas putida (DOT-T1E strain) as the receptor. TtgR is a multidrug-binding protein and regulates one of the key mechanisms of its antibiotic resistance by active extrusion of toxic compounds through the membrane-bound efflux pumps. Although the bacteria exhibits resistance against a number of antibiotics, one natural pyranochalcone Pongachalcone I has been reported to be active against it. The presence of alkoxy moiety in the aromatic side unit of the pyranochalcones seems to be instrumental in binding
%K TtgR
%K docking
%K in-silico
%K antibiotic resistance
%U https://www.dovepress.com/molecular-docking-studies-on-the-activity-of-naturally-occurring-pyran-peer-reviewed-article-OAB