%0 Journal Article
%T Hepatocellular carcinoma: current trends in worldwide epidemiology, risk factors, diagnosis, and therapeutics
%A Dhanasekaran R
%A Limaye A
%A Cabrera R
%J Hepatic Medicine: Evidence and Research
%D 2012
%I 
%R http://dx.doi.org/10.2147/HMER.S16316
%X tocellular carcinoma: current trends in worldwide epidemiology, risk factors, diagnosis, and therapeutics Review (2631) Total Article Views Authors: Dhanasekaran R, Limaye A, Cabrera R Published Date May 2012 Volume 2012:4 Pages 19 - 37 DOI: http://dx.doi.org/10.2147/HMER.S16316 Received: 12 October 2011 Accepted: 14 January 2012 Published: 08 May 2012 Renumathy Dhanasekaran, Alpna Limaye, Roniel Cabrera Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Florida, Gainesville, FL, USA Abstract: Hepatocellular carcinoma (HCC) is a common malignancy in developing countries and its incidence is on the rise in the developing world. The epidemiology of this cancer is unique since its risk factors, including hepatitis C and B, have been clearly established. The current trends in the shifting incidence of HCC in different regions of the world can be explained partly by the changing prevalence of hepatitis. Early detection offers the only hope for curative treatment for patients with HCC, hence effective screening strategies for high-risk patients is of utmost importance. Liver transplantation and surgical resection remains the cornerstone of curative treatment. But major advances in locoregional therapies and molecular-targeted therapies for the treatment of advanced HCC have occurred recently. In this review, current trends in the worldwide epidemiology, surveillance, diagnosis, standard treatments, and the emerging therapies for HCC are discussed.
%K liver cancer
%K sorafenib
%K hepatitis C
%K TACE
%U https://www.dovepress.com/hepatocellular-carcinoma-current-trends-in-worldwide-epidemiology-risk-peer-reviewed-article-HMER