%0 Journal Article
%T Vasogenic shock physiology
%A Sotiria Gkisioti
%A Spyros D Mentzelopoulos
%J Open Access Emergency Medicine
%D 2011
%I Dove Medical Press
%R http://dx.doi.org/10.2147/OAEM.S10388
%X sogenic shock physiology Review (5477) Total Article Views Authors: Sotiria Gkisioti, Spyros D Mentzelopoulos Published Date January 2011 Volume 2011:3 Pages 1 - 6 DOI: http://dx.doi.org/10.2147/OAEM.S10388 Sotiria Gkisioti, Spyros D Mentzelopoulos Department of Intensive Care Medicine, University of Athens Medical School, Evaggelismos General Hospital, Athens, Greece Abstract: Shock means inadequate tissue perfusion by oxygen-carrying blood. In vasogenic shock, this circulatory failure results from vasodilation and/or vasoplegia. There is vascular hyporeactivity with reduced vascular smooth muscle contraction in response to ¦Á1 adrenergic agonists. Considering vasogenic shock, one can understand its utmost importance, not only because of its association with sepsis but also because it can be the common final pathway for long-lasting, severe shock of any cause, even postresuscitation states. The effective management of any patient in shock requires the understanding of its underlying physiology and pathophysiology. Recent studies have provided new insights into vascular physiology by revealing the interaction of rather complicated and multifactorial mechanisms, which have not been fully elucidated yet. Some of these mechanisms, such as the induction of nitric oxide synthases, the activation of adenosine triphosphate-sensitive potassium channels, and vasopressin deficiency, have gained general acceptance and are considered to play an important role in the pathogenesis of vasodilatory shock. The purpose of this review is to provide an update on the pathogenesis of vasogenic shock.
%K nitric oxide synthases
%K KATP channels
%K vasopressin
%K H2S
%K vasoplegic syndrome
%U https://www.dovepress.com/vasogenic-shock-physiology-peer-reviewed-article-OAEM