%0 Journal Article
%T Five-year follow-up of treatment outcomes in patients with early-stage breast cancer and clinically negative axillary nodes treated with no lymph node dissection or axillary clearance
%A Yamamoto D
%A Tanaka K
%A Tsubota Y
%A Sueoka N
%A Shoji T
%A Kuwana K
%A Kwon AH
%J Breast Cancer: Targets and Therapy
%D 2012
%I 
%R http://dx.doi.org/10.2147/BCTT.S36054
%X r follow-up of treatment outcomes in patients with early-stage breast cancer and clinically negative axillary nodes treated with no lymph node dissection or axillary clearance Original Research (2135) Total Article Views Authors: Yamamoto D, Tanaka K, Tsubota Y, Sueoka N, Shoji T, Kuwana K, Kwon AH Published Date August 2012 Volume 2012:4 Pages 125 - 129 DOI: http://dx.doi.org/10.2147/BCTT.S36054 Received: 18 July 2012 Accepted: 30 July 2012 Published: 27 August 2012 Daigo Yamamoto,1 Kanji Tanaka,2 Yu T subota,1 Noriko Sueoka,1 Tetsuji Shoji,3 Kayoko Kuwana,1 A-Hon Kwon1 1Department of Surgery, Kansai Medical University, Hirakata, 2Ribon-Rose Tanaka Kanji Breast Clinic, 3Shoji Clinic, Osaka, Japan Background: Sentinel lymph node biopsy has steadily replaced axillary lymph node dissection (ALND) for staging clinically node-negative breast cancer. However, ALND remains standard management of the axilla when a tumor-positive sentinel lymph node is identified. Methods: We identified 460 patients with breast cancer (clinically T1/T2N0M0) from the database for 1999¨C2004. Patient age ranged from 26 to 81 (median 50) years. Patients who underwent mastectomy or breast-conserving surgery with or without ALND were compared for regional recurrence, disease-free survival, and overall survival. Results: Patients with ALND (n = 308) were compared with the no ALND group (n = 152). Five-year overall survival and disease-free survival were not significantly different between the two groups, while there was a significant difference between them for regional recurrence. Of the 152 patients who did not undergo axillary dissection, four developed ipsilateral axillary disease, most of whom were rescued by delayed axillary dissection. Further, the criterion for identifying lymphedema was used, ie, a 2 cm circumferential change at any measured location. As a result, the incidence of lymphedema in the ALND group was 12.7%, while it was not seen in the non ALND group. Conclusion: There is a possibility that ALND may be omitted for cT1/T2N0M0 breast cancer through a combination of hormone therapy and adjuvant chemotherapy.
%K breast cancer
%K axillary lymph node dissection
%U https://www.dovepress.com/five-year-follow-up-of-treatment-outcomes-in-patients-with-early-stage-peer-reviewed-article-BCTT