%0 Journal Article
%T Combination therapies, effectiveness, and adherence in patients with HIV infection: clinical utility of a single tablet of emtricitabine, rilpivirine, and tenofovir
%A Wainberg MA
%J HIV/AIDS - Research and Palliative Care
%D 2013
%I Dove Medical Press
%R http://dx.doi.org/10.2147/HIV.S32377
%X mbination therapies, effectiveness, and adherence in patients with HIV infection: clinical utility of a single tablet of emtricitabine, rilpivirine, and tenofovir Review (893) Total Article Views Authors: Wainberg MA Published Date February 2013 Volume 2013:5 Pages 41 - 49 DOI: http://dx.doi.org/10.2147/HIV.S32377 Received: 15 December 2012 Accepted: 09 January 2013 Published: 07 February 2013 Mark A Wainberg McGill University AIDS Centre, Lady Davis Institute, Jewish General Hospital, Montreal, Quebec, Canada Abstract: A recent addition to the anti-human immunodeficiency virus armamentarium of drugs is rilpivirine, which is a potent non-nucleoside reverse transcriptase inhibitor. This review focuses on the clinical utility of rilpivirine in terms of efficacy and virologic suppression, drug resistance, drug-drug interactions, and safety. The rilpivirine-tenofovir-emtricitabine combination is a safe and effective regimen for use in most patients who are ready to start first-line anti-human immunodeficiency virus therapy. Although drug resistance can be a problem in patients who initiate therapy on rilpivirine-based regimens with viral loads > 100,000 copies of viral RNA/mL, this problem can be alleviated by first starting therapy with efavirenz-tenofovir-emtricitabine for several months to suppress viral load to <50 copies/mL before switching to rilpivirine-based therapy. E138K is the most important mutation associated with resistance against rilpivirine and its development must be avoided whenever possible, because this mutation confers broad cross-resistance against all approved members of the non-nucleoside reverse transcriptase inhibitor family of drugs.
%K non-nucleoside reverse transcriptase inhibitors
%K rilpivirine
%K human immunodeficiency virus
%K treatment
%K resistance
%U https://www.dovepress.com/combination-therapies-effectiveness-and-adherence-in-patients-with-hiv-peer-reviewed-article-HIV