%0 Journal Article
%T Spectrophotometric Determination of Ciprofloxacin Hydrochloride in Ophthalmic Solution
%J Advances in Analytical Chemistry
%@ 2163-2847
%D 2012
%I 
%R 10.5923/j.aac.20120206.01
%X The objective of this study was to develop simple and rapid method for the determination of ciprofloxacin hydrochloride in ophthalmic solution using UV spectrophotometry. The intrinsic absorbance of ciprofloxacin was measured directly at 275 nm. The calibration graph was linear over the range 2.0¨C7.0 ¦Ìg mL-1 with relative standard deviations (RSD) values ranging from 1.55 to 2.47% (n=6). The method was validated through the parameters of linearity, accuracy, precision, limit of detection, limit of quantitation,specificity and robustnessaccording to ICH. The proposed method is enabled a quantitative determination of ciprofloxacin hydrochloride in ophthalmic solution.
%K UV Spectrophotometry
%K Quinolones
%K Analytical Method
%K Ciprofloxacin Hydrochloride
%U http://article.sapub.org/10.5923.j.aac.20120206.01.html