%0 Journal Article
%T Stereoselective Synthesis of Bicyclic Lactones Via Annelation Protocol
%J American Journal of Organic Chemistry
%@ 2163-1301
%D 2012
%I 
%R 10.5923/j.ajoc.20120206.01
%X A successful two-step annelation protocol of diesters and methyl bromoacetate with 2- chlorocyclopentanone derivatives was efficiently pursued, which gave suitably substituted bicyclic lactones in high overall yields and with complete streoselectivity mediated by K-Selectride and Wilkinsons catalyst, is reported. As part of a program aimed at rapid synthesis of bicyclic lactones which inherently occurs in many active natural products, this paper has shown a novel and rare methods for the synthesis of these important compounds based on alkylation of cyclopentanone derivatives and further demonstrate efficient reduction protocol of these compounds to the bicyclci lactones
%K Annelation
%K Diesters
%K Methyl Bromo Acetate
%K Bicyclic Lactones
%U http://article.sapub.org/10.5923.j.ajoc.20120206.01.html