%0 Journal Article
%T Misoprostol Sublingually Versus Vaginally for Labor Induction at Term: A Randomized Study
%J Research in Obstetrics and Gynecology
%@ 2326-1218
%D 2012
%I 
%R 10.5923/j.rog.20120103.03
%X Objective: To compare the efficacy of misoprostol 50 ¦Ìg vaginally and 50 ¦Ìg sublingually for labor induction at term. Materials and Methods: One hundred and twenty women were randomized to receive misoprostol 50 ¦Ìg vaginally (n = 60) or 50 ¦Ìg sublingually misoprostol (n = 60). The doses were given every 5 h (maximum 5 doses). Primary outcome measure was vaginal delivery rate. Induction to delivery time, delivery within 12 h, the number of misoprostol doses given and neonatal outcomes were secondary outcome measures. Results: Vaginal delivery rates were 75% in the sublingual group and 73% in the vaginal group (RR, 1.09; 95% CI, 0.4 - 2.4).The number of women delivering within 12 h was 20 (45.5%) in the vaginal group and 12 (27%) in the sublingual group (RR, 0.5; 95% CI, 0.3 ¨C 1). There were no significant differences in the number of doses needed, incidence of contractility disturbances, or neonatal results. Conclusion: Sublingual misoprostol is as efficacious as vaginal misoprostol for induction of labor and neonatal outcomes are similar.
%K Sublingual Misoprostol
%K Vaginal Misoprostol
%K Induction Of Labor
%K Effectiveness
%K Safety
%U http://article.sapub.org/10.5923.j.rog.20120103.03.html