%0 Journal Article
%T Synthesis and Spectral Characterization of Novel 2, 3-Disubstituted Quinazolin-4(3H) one Derivatives
%J American Journal of Organic Chemistry
%@ 2163-1301
%D 2012
%I 
%R 10.5923/j.ajoc.20120201.01
%X New series of 2,3-disubstituted quinazolin-4(3H)- one were synthesized via the reaction of the readily obtainable 2-thioxo-3-phenyl-quinazolin-4(3H)one 1 with ethyl chloroacetate followed by hydrazinolysis to afford the hydrazide 3 which allowed to react with different electrophilic reagents such as carbon disulphide, phenyl isothiocyanate, ¦Â-diketones, anhydrides, acrylonitrile, ethyl cinnamate, dimethyl acetylene dicarboxylate, aldehydes, arylidene malononitrile and lauroyl chloride. Some of the newly synthesized compounds showed promising anti-inflammatory activity.
%K Pyrzolyl-
%K 1
%K 3
%K 4-Oxadiazolyl Quinazolinone
%K Anti-Inflammatory
%K Michael Reaction
%U http://article.sapub.org/10.5923.j.ajoc.20120201.01.html