%0 Journal Article
%T Efficient Method for the Synthesis of Diazaphospholidines: Toxicological Evaluation
%J American Journal of Organic Chemistry
%@ 2163-1301
%D 2012
%I 
%R 10.5923/j.ajoc.20120201.03
%X In this work, we described the synthesis of new heterocyclic organophosphorus compounds starting from a primary amine and  phenyl phosphonic dichloride (PDCP). The introduction of a phosphoryl group into heterocyclic structures can generate potential chemical and biological activities. We have prepared the phosphoramidates in only one step. These compounds provide access to diazaphospholidine by intermolecular cyclization using dibromoethane. We chose primary amines (cyclohexylamine, benzylamine, propylamine and phenyl ethylamine) to prepare phosphoramidates. The toxicological activity of two synthesized molecules was evaluated.
%K Phenyl Phosphonic Dichloride
%K Phosphoramidate
%K Diazaphospholidine
%U http://article.sapub.org/10.5923.j.ajoc.20120201.03.html