%0 Journal Article
%T Synthesis, Cytotoxicity Evaluation, DFT Molecular Modeling Studies and Quantitative Structure Activity Relationship of Novel 1,8-Naphthyridines
%J American Journal of Organic Chemistry
%@ 2163-1301
%D 2012
%I 
%R 10.5923/j.ajoc.20120204.03
%X A series of substituted 1,8-naphthyridine derivatives were synthesized from 4-oxo-1,4-dihydro-1,8- naphthyridine-3-carbohydrazide (4) as starting material and investigated as cytotoxic and antitumor agents. Compound 4 reacted with different acid anhydrides to afford the corresponding imides and bis-imide derivatives 5-11. Pyridine and 1,8-naphthyridine derivatives 2-11 were tested for their in vitro cytotoxicity against four different cancer cell lines and structure activity relationship¡¯s (SAR¡¯s) was studied. Compounds 4-11 were studied theoretically using the density functional theory (DFT) with B3LYP/6-31(d) level of calculations, and the electronic properties of these compounds were related to their biological activity.
%K 2-Aminopyridine
%K Diethylethoxymethylenemalonate
%K 1
%K 8-Naphthyridine
%K Acid Anhydrides
%K Cytotoxicity
%K Molecular Modeling
%U http://article.sapub.org/10.5923.j.ajoc.20120204.03.html