%0 Journal Article
%T The Characteristics and Functions of Molecular Biology for Liver-specific miR-122<br>肝脏特异性miR-122的分子生物学特性及功能
%A 徐洁
%A 吴福生
%A 蔡荣
%J 生物物理学报
%D 2009
%I 
%X miR-122 is specifically and abundantly expressed in the human liver. The recent investigations have demonstrated that under the physiological condition, miR-122 may play important roles in regulating hepatocyte development, differentiation, metabolism, stress responses, and under the pathological condition, the abnormal expression of miR-122 is closely related to hepatitis C virus (HCV) or hepatocellular carcinoma (HCC), and miR-122 is likely to facilitate replication of HCV RNA or is as a tumor suppressor gene for hepatocarcinogenesis. In addition, miR-122 could have diagnostic and prognostic significance for HCC. Respecting the effects of miR-122 on the major diseases of the human liver, the authors reviewed and analyzed the biological characteristics, diverse functions and possible mechanisms of miR-122. This liver-specific microRNA, miR-122, could be exploited as a key target for the treatment of human liver diseases.
%K miR-122
%K hcr
%K CAT-1
%K HCV
%K HCC<br>miR-122
%K hcr
%K 阳离子氨基酸转运体-1
%K 丙型肝炎病毒
%K 肝细胞肝癌
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=E0C9D9BBED813D6674AC13E942EAC86D&aid=A3D9A748AF8CE9747461CDDF7A120A23&yid=DE12191FBD62783C&vid=C5154311167311FE&iid=38B194292C032A66&sid=DD74772618543076&eid=AC1578C6BB9EBDEF&journal_id=1000-6737&journal_name=生物物理学报&referenced_num=0&reference_num=0