%0 Journal Article
%T Detection of Reactive Oxygen Species Induced by Cadmium Tellurium Quantum Dots<br>碲化镉量子点诱导氧自由基产生的检测
%A Liu N
%A Zhao Shurui
%A Lin Tong
%A Feng Shuang
%A Mu Ying
%A Han Sihai
%A Huang Peili
%A Sun Zhiwei
%A <br>刘娜
%A 赵淑锐
%A 林彤
%A 冯爽
%A 牟颖
%A 韩四海
%A 黄沛力
%A 孙志伟
%J 生态毒理学报
%D 2012
%I 
%X With the extensive application of quantum dots (QDs) in biomarker and bioimaging, the amount of human exposure to QDs increases, so the exploration of the mechanism of their biological toxicity is of significant concern. The generation of ROS (reactive oxygen species) induced by QDs is accepted to act as a mechanism to produce toxicity. To investigate the relationship between the toxicity of QDs and the production of ROS, cadmium-telluride QDs (CdTe QDs and CdTe/ZnS QDs) were selected, and the type and intensity of ROS were detected using electron paramagnetic resonance (EPR) when adding various concentrations of CdTe QDs or CdTe/ZnS QDs in the cell-free system. The promotive effect of CdTe QDs or CdTe/ZnS QDs on the production of superoxide anion (·O2-) and hydroxyl free radicals (·OH) was studied by EPR, ultraviolet and fluorescence spectrophotometer. Results showed that CdTe QDs could induce the production of ·O2-. The generation of ·OH and ·O2- could be obviously promoted by CdTe QDs and CdTe/ZnS QDs. The intensity of ·OH (or ·O2-) and the dose of QDs showed a clear dose-effect relationship. It was indicated that QDs could induce and promote the production of ROS. The inducing and promoting effect was dependent on the structure of QDs.
%K quantum dots
%K hydroxyl free radicals
%K superoxide anion
%K electron paramagnetic resonance<br>量子点
%K 羟基自由基
%K 超氧阴离子
%K 电子顺磁共振
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=3FF3ABA7486768130C3FF830376F43B398E0C97F0FF2DD53&cid=BEC1F4700DD66C14D137590A0896A0AD&jid=B98D390DF92C35E6DD1987675E4EE86E&aid=73BD5F74249A2B512A0039D3B536920A&yid=99E9153A83D4CB11&vid=DF92D298D3FF1E6E&iid=CA4FD0336C81A37A&sid=A4FA325EA800C820&eid=F24949CFDB502409&journal_id=1673-5897&journal_name=生态毒理学报&referenced_num=0&reference_num=0