%0 Journal Article
%T Genetic analysis of epistatic effects between ApoB and UCP on abdominal fat trait in chicken<br>ApoB与UCP基因间上位效应对鸡腹脂性状影响的遗传学分析
%A HU Guo
%A WANG Shou-Zhi
%A ZHANG Sen
%A CHEN Wei-Xing
%A LIU Shuang
%A TIAN Jian-Wei
%A LI Hui College of Animal Science
%A Technology
%A Northeast Agricultural University
%A Harbin
%A China
%A <br>户国
%A 王守志
%A 张森
%A 陈维星
%A 刘爽
%A 田建伟
%A 李辉
%J 遗传
%D 2010
%I 
%X It has been found that epistasis for selective response plays an indispensible role in animal genetics and breeding. In this study, the polymorphisms of T123G in apoliprotein B (ApoB) and C1197A in uncoupling protein (UCP) among individuals from the 8th to the 10th generation populations of the Northeast Agricultural University broiler lines divergently selected for abdominal fat content (NEAUHFL) were detected, and genetic analysis of the epistatic effects between the two SNPs on abdominal fat percentage (AFP) was performed using Natural and Orthogonal InterActions (NOIA) model. According to these assays, we concluded that at least one out of four epistatic components between these two SNPs was significantly associated with AFP (P<0.05) in fat lines from the 8th to the 10th generations of NEAUHFL; on the contrary, none was significantly associated with AFP (P>0.05) in lean lines. Our results suggested that epistatic interactions among QTLs and functional SNPs in candidate genes affecting fat traits might lead to differences in growth patterns of fat traits between lean and fat chicken lines.
%K ApoB
%K UCP
%K SNP
%K chicken
%K fat
%K gene interaction
%K ApoB
%K UCP
%K SNP<br>鸡
%K 脂肪
%K 基因互作
%K ApoB
%K UCP
%K SNP
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=3E23F50E071DF18E21B2F5AEE4F1FA5E&aid=3748745968B80AE114BAC7D32F8514F0&yid=140ECF96957D60B2&vid=9971A5E270697F23&iid=CA4FD0336C81A37A&sid=6AC2A205FBB0EF23&eid=5C3443B19473A746&journal_id=0253-9772&journal_name=遗传&referenced_num=0&reference_num=56