%0 Journal Article
%T Silicon-[18F]Fluorine Radiochemistry: Basics, Applications and Challenges
%A Carmen W£¿ngler
%A Alexey Kostikov
%A Jun Zhu
%A Joshua Chin
%A Bj£¿rn W£¿ngler
%A Ralf Schirrmacher
%J Applied Sciences
%D 2012
%I MDPI AG
%R 10.3390/app2020277
%X Silicon-[ 18F]fluorine (Si- 18F) radiochemistry has recently emerged alongside other unconventional approaches such as aluminum- 18F and boron- 18F based labeling strategies, reshaping the landscape of modern 18F-radiochemistry. All these novel methodologies are driven by the demand for more convenient 18F-labeling procedures to further disseminate one of the most sophisticated imaging technologies, Positron Emission Tomography (PET). The PET methodology requires special radionuclides such as 18F (one of the most prominent examples) to be introduced into bioactive molecules. Si- 18F radiochemistry contributed greatly towards the development of new radiopharmaceuticals for PET imaging. Herein, we describe the radiochemical basics of Si- 18F bond formation, the application of Si- 18F tracers for PET imaging, and additionally, the inherent chemical intricacies of this methodology.
%K fluorine-18
%K silicon
%K positron emission tomography (PET)
%U http://www.mdpi.com/2076-3417/2/2/277