%0 Journal Article
%T New antimyeloma drugs in spinal cord infiltration for multiple myeloma. Determination of lenalidomide in cerebrospinal fluid with ultrasensitive high-performance liquid chromatography
%A Juan Jos¨¦ Lahuerta
%A Inmaculada Rapado
%A Laura Montejano
%A Mar¨ªa ¨¢ngeles Montalb¨¢n
%A Laura Pares
%A Joaqu¨ªn Mart¨ªnez- L¨®pez
%J Modern Chemotherapy
%P 11-13
%@ 2169-3498
%D 2012
%I Scientific Research Publishing
%R 10.4236/mc.2012.12003
%X A 64-year-old woman with IgA kappa multiple myeloma was treated with thalidomide-dexa- methasone. Due to progression of the disease, bortezomib, doxorubicin and dexamethasone were administered, followed by autologous stem cell transplantation. Although near-complete remission was achieved, 5 months later, neuro- logical symptoms appeared and the patient was diagnosed with multiple myeloma with cells in- filtrating the spinal cord. Bis-chloronitrosourea, bortezomib and lenalidomide were then admin- istered and although the patient remained neu- rologically asymptomatic, she died 3 months later becausee of disease progression. Lena- lidomide entered into the cerebrospinal fluid (confirmed by ultrasensitive high-performance liquid chromatography), although did not im- prove the poor prognosis of multiple myeloma involving the central nervous system.
%K Lenalidomide
%K Multiple Myeloma
%K Spinal Cord Infiltration
%K High-Performance Liquid Chromatography
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=23392