%0 Journal Article
%T The Inhibitor of Apoptosis (IAPs) in Adaptive Response to Cellular Stress
%A Arthur Marivin
%A Jean Berthelet
%A St¨¦phanie Plenchette
%A Laurence Dubrez
%J Cells
%D 2012
%I MDPI AG
%R 10.3390/cells1040711
%X Cells are constantly exposed to endogenous and exogenous cellular injuries. They cope with stressful stimuli by adapting their metabolism and activating various ¡°guardian molecules.¡± These pro-survival factors protect essential cell constituents, prevent cell death, and possibly repair cellular damages. The Inhibitor of Apoptosis (IAPs) proteins display both anti-apoptotic and pro-survival properties and their expression can be induced by a variety of cellular stress such as hypoxia, endoplasmic reticular stress and DNA damage. Thus, IAPs can confer tolerance to cellular stress. This review presents the anti-apoptotic and survival functions of IAPs and their role in the adaptive response to cellular stress. The involvement of IAPs in human physiology and diseases in connection with a breakdown of cellular homeostasis will be discussed.
%K IAPs
%K apoptosis
%K caspases
%K NF-kB
%K TNFR
%K UPR
%K DNA damage response
%K cancer
%K neurodegenerative disease
%U http://www.mdpi.com/2073-4409/1/4/711