%0 Journal Article
%T Progress of non-human primate animal models of cancers<br>非人灵长类肿瘤模型研究进展
%A XIA Hou-Jun
%A CHEN Ce-Shi
%A <br>夏厚军
%A 陈策实
%J 动物学研究
%D 2011
%I Chinese Academy of Sciences
%X Cancer is the second leading disease causing human death.Pre-clinical in vivo studies are essential for translating in vitro laboratory research results into the clinic.Rodents,including the mouse and rat,have been widely used for pre-clinical studies due to their small size,clear genetic backgrounds,rapid propagation,and mature transgenic technologies.However,because rodents are evolutionarily distinct from humans,many pre-clinical research results using rodent models cannot be reproduced in the clinic.Non-human primates(NHPs)may be better animal models than rodents for human cancer research because NHPs and humans share greater similarity in regards to their genetic evolution,immune system,physiology and metabolism.This article reviews the latest progress of cancer research in NHPs by focusing on the carcinogenesis of different NHPs induced by chemical and biological carcinogens.Finally,future research directions for the use of NHPs in cancer research are discussed.
%K Non-human primate
%K Cancer
%K Tree shrew<br>非人灵长类
%K 肿瘤
%K 树鼩
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=7C502F1A6798ACE1B8C57E291C48C7F1&aid=CBA275E0E442BE3DB6C8B8EE3A437B41&yid=9377ED8094509821&vid=9971A5E270697F23&iid=CA4FD0336C81A37A&sid=09ABD5535D9B6D45&eid=E203FB1A272C9DD2&journal_id=0254-5853&journal_name=动物学研究&referenced_num=0&reference_num=103