%0 Journal Article
%T Establishment of tree shrew chronic morphine dependent model<br>慢性吗啡依赖树鼩模型的建立
%A Sun Yong-Mei
%A Yang Jian-Zhen
%A Sun Hua-Ying
%A Ma Yuan-Ye
%A Wang Jian-Hong
%A <br>Sun YM
%A Yang JZ
%A Sun HY
%A Ma YY
%A Wang JH
%J 动物学研究
%D 2012
%I Chinese Academy of Sciences
%X The clinical use of morphine to reduce pain is limited because of its drug tolerance, dependence and addiction. In the present study, the tree shrews (Tupaia belangeri chinensis) developed morphine tolerance and chronic morphine dependence by morphine injections with increasing doses (5, 10, 15, 20 mg/kg body weight for 7 days). Meanwhile, the naloxone (1.25 mg/kg body weight)-induced conditioned place aversion (CPA) and the withdrawal symptom were also found. The tree shrew model of chronic morphine dependence can be used to investigate the withdrawal symptoms and to select potential withdrawal symptoms reducing drugs in the future.
%K Tree shrew
%K Morphine
%K Chronic dependence
%K Conditioned place aversion
%K Withdrawal symptom<br>树鼩
%K 吗啡
%K 慢性依赖
%K 条件性位置厌恶
%K 戒断症状
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=7C502F1A6798ACE1B8C57E291C48C7F1&aid=1D36885FD7A8294BFC5AE26B0F5F877C&yid=99E9153A83D4CB11&vid=27746BCEEE58E9DC&iid=CA4FD0336C81A37A&sid=F3583C8E78166B9E&eid=13553B2D12F347E8&journal_id=0254-5853&journal_name=动物学研究&referenced_num=0&reference_num=33