%0 Journal Article
%T Animal Toxins and Human Disease: from Single Component to Venomics, from Biochemical Characterization to Disease Mechanisms, from Crude Venom Utilization to Rational Drug Design<br>动物毒素与人类疾病——从单一成分到组学研究,从理化性质到疾病机理,从粗毒利用到理性药物设计
%A 吕秋敏
%A 赖仞
%A 张云
%J 动物学研究
%D 2010
%I Chinese Academy of Sciences
%X Many animals produced a diversity of venoms and secretions to adapt the changes of environments through the long history of evolution. The components including a large quantity of specific and highly active peptides and proteins have become good research models for protein structure-function and also served as tools and novel clues for illustration of human disease mechanisms. At the same time, they are rich natural resources for new drug development. Through the valuable venomous animal resources of China, researchers at the Kunming Institute of Zoology, CAS have carried out animal toxin research over 30 years. This paper reviews the main work conducted on snake venoms, amphibian and insect secretions, and the development from single component to venomics, from biochemical characterization to human disease mechanisms, from crude venom to rational drug design along with a short perspective on future studies.
%K Animal toxin
%K Venom
%K Amphibian
%K Skin secretion
%K Arthropod
%K Insect
%K Salivary gland<br>动物毒素
%K 蛇毒
%K 两栖动物
%K 皮肤分泌物
%K 节肢动物
%K 昆虫
%K 唾液腺
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=7C502F1A6798ACE1B8C57E291C48C7F1&aid=A30D2348009E41A68ED3F706625EA966&yid=140ECF96957D60B2&vid=4AD960B5AD2D111A&iid=CA4FD0336C81A37A&sid=0B39A22176CE99FB&eid=7801E6FC5AE9020C&journal_id=0254-5853&journal_name=动物学研究&referenced_num=1&reference_num=136