%0 Journal Article
%T Comparison of gene expression between naturally occurring and diet-induced T2DM in cynomolgus monkeys<br>自发性与膳食诱发性食蟹猴2 型糖尿病其相关基因的表达比较
%A Ji Fang
%A Jin Li-Sha
%A Zeng Xiao-Ming
%A Zhang Xiu-Juan
%A Zhang Yan-Chun
%A Sun Yun-Xiao
%A Gao Li-Hua
%A He Hong
%A Rao Jun-Hua
%A Liu Xiao-Ming
%A Peng Bai-Lu
%A <br>Ji F
%A Jin LS
%A Zeng XM
%A Zhang XJ
%A Zhang YC
%A Sun YX
%A Gao LH
%A He H
%A Rao JH
%A Liu XM
%A Peng BL
%J 动物学研究
%D 2012
%I Chinese Academy of Sciences
%X To explore pathological alteration of T2DM in cynomolgus monkeys, gene expression profiles of peripheral blood leukocytes from spontaneous and diet-induced T2DM models was analyzed using quantitative real-time PCR. Among 36 T2DM associated genes tested, 19 genes (including G6PC, CCR2B, CTLA4) displayed a similar expression pattern in both spontaneous and diet-induced T2DM models and were significantly up-regulated or down-regulated compared to controls. Interestingly, expression abundance of all up-regulated genes in the diet-induced T2DM was stronger, although not significantly, than spontaneous models, indicating diet-induced T2DM in monkeys should be a reliable research model for changes in gene expression. The characteristic gene expression pattern obtained here may be useful for the clinical diagnosis of T2DM.
%K Type 2 diabetes mellitus (T2DM)
%K Gene expression profile
%K Cynomolgus monkey<br>2
%K 型糖尿病
%K 基因表达
%K 食蟹猴
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=7C502F1A6798ACE1B8C57E291C48C7F1&aid=1D36885FD7A8294B86849E8784F74210&yid=99E9153A83D4CB11&vid=27746BCEEE58E9DC&iid=CA4FD0336C81A37A&sid=9C65ADEB5990B252&eid=656F8C8401D91023&journal_id=0254-5853&journal_name=动物学研究&referenced_num=0&reference_num=54