%0 Journal Article
%T New Generations: Sequencing Machines and Their Computational Challenges
%A David CSchwartz
%A Michael SWaterman
%A <br>David C. Schwartz
%A Michael S. Waterman
%J 计算机科学技术学报
%D 2010
%I 
%X New generation sequencing systems are changing how molecular biology is practiced. The widely promoted ＄1000 genome will be a reality with attendant changes for healthcare, including personalized medicine. More broadly the genomes of many new organisms with large samplings from populations will be commonplace. What is less appreciated is the explosive demands on computation, both for CPU cycles and storage as well as the need for new computational methods. In this article we will survey some of these develo...
%K genome sequencing
%K new generation sequencing
%K read mapping
%K optical mapping
%K sequence assembly
%K Eulerian graphs<br>计算方法
%K 测序
%K 世代
%K 分子生物学
%K 个性化医疗
%K 卫生保健
%K 抽样调查
%K 基因组
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=5B3AB970F71A803DEACDC0559115BFCF0A068CD97DD29835&cid=8240383F08CE46C8B05036380D75B607&jid=F57FEF5FAEE544283F43708D560ABF1B&aid=5C01ED6FBC19EAD756A24B500DC7E2F8&yid=140ECF96957D60B2&vid=C5154311167311FE&iid=CA4FD0336C81A37A&sid=38B194292C032A66&eid=9CF7A0430CBB2DFD&journal_id=1000-9000&journal_name=计算机科学技术学报&referenced_num=1&reference_num=47