%0 Journal Article
%T Challenges in Understanding Genome-Wide DNA Methylation
%A Michael QZhang
%A Andrew DSmith
%A <br>张伟奇
%A Andrew D. Smith
%J 计算机科学技术学报
%D 2010
%I 
%X DNA methylation is a chemical modification of the bases in genomes. This modification, most frequently found at CpG dinucleotides in eukaryotes, has been identified as having multiple critical functions in broad and diverse species of animals and plants, while mysteriously appears to be lacking from several other well-studied species. DNA methylation has well known and important roles in genome stability and defense, its pattern change highly correlates with gene regulation. Much evidence has linked abnorma...
%K DNA methylation
%K epigenome
%K computational epigenomics<br>DNA甲基化
%K 全基因组
%K 植物物种
%K 化学修饰
%K 真核生物
%K 人民政府
%K 基因调控
%K 共同特征
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=5B3AB970F71A803DEACDC0559115BFCF0A068CD97DD29835&cid=8240383F08CE46C8B05036380D75B607&jid=F57FEF5FAEE544283F43708D560ABF1B&aid=1B4C170E261D47AEA9D8D4E1CC49DB50&yid=140ECF96957D60B2&vid=C5154311167311FE&iid=CA4FD0336C81A37A&sid=96C778EE049EE47D&eid=339D79302DF62549&journal_id=1000-9000&journal_name=计算机科学技术学报&referenced_num=1&reference_num=63