%0 Journal Article
%T Estimation of (co)variances for genomic regions of flexible sizes: application to complex infectious udder diseases in dairy cattle
%A Lars P S£¿rensen
%A Luc Janss
%A Per Madsen
%A Thomas Mark
%A Mogens S Lund
%J Genetics Selection Evolution
%D 2012
%I BioMed Central
%R 10.1186/1297-9686-44-18
%X Data on progeny means of six traits related to mastitis resistance in dairy cattle (general mastitis resistance and five pathogen-specific mastitis resistance traits) were analyzed using a bivariate Bayesian SNP-based genomic model with a common prior distribution for the marker allele substitution effects and estimation of the hyperparameters in this prior distribution from the progeny means data. From the Markov chain Monte Carlo samples of the allele substitution effects, genomic (co)variances were calculated on a whole-genome level, per chromosome, and in regions of 100 SNP on a chromosome.Genomic proportions of the total variance differed between traits. Genomic correlations were lower than pedigree-based genetic correlations and they were highest between general mastitis and pathogen-specific traits because of the part-whole relationship between these traits. The chromosome-wise genomic proportions of the total variance differed between traits, with some chromosomes explaining higher or lower values than expected in relation to chromosome size. Few chromosomes showed pleiotropic effects and only chromosome 19 had a clear effect on all traits, indicating the presence of QTL with a general effect on mastitis resistance. The region-wise patterns of genomic variances differed between traits. Peaks indicating QTL were identified but were not very distinctive because a common prior for the marker effects was used. There was a clear difference in the region-wise patterns of genomic correlation among combinations of traits, with distinctive peaks indicating the presence of pleiotropic QTL.The results show that it is possible to estimate, genome-wide and region-wise genomic (co)variances of mastitis resistance traits in dairy cattle using multivariate genomic models.Livestock provide a great source of data to investigate genome-wide effects on various phenotypic characteristics such as infectious diseases. There are several reasons for this, including: (1) vast amounts
%U http://www.gsejournal.org/content/44/1/18