%0 Journal Article
%T Comparison on genomic predictions using three GBLUP methods and two single-step blending methods in the Nordic Holstein population
%A Hongding Gao
%A Ole F Christensen
%A Per Madsen
%A Ulrik S Nielsen
%A Yuan Zhang
%A Mogens S Lund
%A Guosheng Su
%J Genetics Selection Evolution
%D 2012
%I BioMed Central
%R 10.1186/1297-9686-44-8
%X The data consisted of de-regressed proofs (DRP) for 5 214 genotyped and 9 374 non-genotyped bulls. The bulls were divided into a training and a validation population by birth date, October 1, 2001. Five approaches for genomic prediction were used: 1) a simple GBLUP method, 2) a GBLUP method with a polygenic effect, 3) an adjusted GBLUP method with a polygenic effect, 4) a single-step blending method, and 5) an adjusted single-step blending method. In the adjusted GBLUP and single-step methods, the genomic relationship matrix was adjusted for the difference of scale between the genomic and the pedigree relationship matrices. A set of weights on the pedigree relationship matrix (ranging from 0.05 to 0.40) was used to build the combined relationship matrix in the single-step blending method and the GBLUP method with a polygenetic effect.Averaged over the 16 traits, reliabilities of genomic breeding values predicted using the GBLUP method with a polygenic effect (relative weight of 0.20) were 0.3% higher than reliabilities from the simple GBLUP method (without a polygenic effect). The adjusted single-step blending and original single-step blending methods (relative weight of 0.20) had average reliabilities that were 2.1% and 1.8% higher than the simple GBLUP method, respectively. In addition, the GBLUP method with a polygenic effect led to less bias of genomic predictions than the simple GBLUP method, and both single-step blending methods yielded less bias of predictions than all GBLUP methods.The single-step blending method is an appealing approach for practical genomic prediction in dairy cattle. Genomic prediction from the single-step blending method can be improved by adjusting the scale of the genomic relationship matrix.Selection based on dense markers across the genome [1] has become an important component of dairy cattle breeding programs [2-7]. The accuracy of genomic prediction relies on the amount of information used to derive the prediction equation. In many
%U http://www.gsejournal.org/content/44/1/8