%0 Journal Article
%T Feasibility of breast conservation after neoadjuvant taxene based chemotherapy in locally advanced breast cancer: a Prospective Phase I trial
%A Mohamed I El-Sayed
%A Doaa W Maximous
%A Mohamed A Aboziada
%A Mostafa E Abdel-Wanis
%A Nabiel NH Mikhail
%J Annals of Surgical Innovation and Research
%D 2010
%I BioMed Central
%R 10.1186/1750-1164-4-5
%X Forty five patients had stage IIB (except those with T2N1 disease) and stage IIIA were selected to 3 cycles taxane-based neoadjuvant chemotherapy. Patient who had tumours ¡Ü5 cm underwent a tentative BCS while patients who had tumour size >5 cm underwent radical surgery. Negative margin is essential for BCS. Adjuvant chemotherapy and 3-D radiotherapy ¡À hormonal treatment were given to all patients.Thirty four patients had BCS. Response to chemotherapy was the only statistically significant factor which influences the BCS. Incidence of local recurrence was 5.9% for patients who had BCS at a median follow up 24 months.Breast conservation is feasible in selected cases of locally advanced, non metastatic cancer breast. We recommend that patients who have tumour size ¡Ü4 cm after chemotherapy are the best candidates for BCS.Long-term survival is common among women with locally advanced breast cancer; therefore, quality of life issues become vitally important. For most women, loss of a breast is emotionally disturbing [1].The patient's response to preoperative chemotherapy is a powerful prognostic factor in predicting disease-free and overall survival from locally advanced breast cancer [2,3]. By assessing the response to preoperative chemotherapy, it is possible to select out a better prognosis group of patients who will have improved long-term survival and a low rate of local recurrence. Therefore, patients who respond to preoperative chemotherapy are often the best candidates for breast conservation, allowing for less disfigurement with preservation of function [3,4].Several studies have documented the feasibility and safety of breast conservation for locally advanced breast cancer after preoperative chemotherapy. Breast conservation is possible in 27% to 90% of patients after preoperative chemotherapy [4,5]. Local recurrence rates after breast conservation are low (5% - 10%) in patients who respond to preoperative chemotherapy [6,7].Our primary outcome was the evaluatio
%U http://www.asir-journal.com/content/4/1/5