%0 Journal Article
%T Ventilator-induced lung injury: historical perspectives and clinical implications
%A Nicolas de Prost
%A Jean-Damien Ricard
%A Georges Saumon
%A Didier Dreyfuss
%J Annals of Intensive Care
%D 2011
%I Springer
%R 10.1186/2110-5820-1-28
%X The prognosis of the acute respiratory distress syndrome (ARDS) has improved dramatically within the past decades, with in-hospital mortality rates ranging from 90% in the seventies [1] to approximately 30% in a recent study [2]. Reduction of the tidal volume delivered to mechanically ventilated patients, and thus of the stress applied to their lungs, unambiguously contributed to improving outcomes, as demonstrated by the ARDSnet study, which showed a 22% higher survival in patients who received lower (6 mL/kg) than in those who received larger (12 mL/kg) tidal volumes [3]. Interestingly, almost one decade before the ARDSnet study was published, the concept of "permissive hypercapnia" [4] had already led to the use of lower tidal volumes by clinicians and well-conducted observational studies had evidenced significant decrease in the mortality of patients suffering from ARDS [5]. Indeed, compelling physiological evidence had been drawn from experimental studies that had described the deleterious effects of mechanical ventilation using high peak inspiratory pressures on lungs, regrouped under the term ventilator-induced lung injury (VILI) [6-8]. In addition to this "volutrauma," so-called "low-volume" injury associated with the repeated recruitment and derecruitment of distal lung units has been incriminated in the development of VILI and forms the rationale for the use of positive end-expiratory pressure (PEEP) [9-11]. We reviewed seminal experimental studies that led to our current understanding of VILI and contributed to the current recommendations in the respiratory support of ARDS patients.Only 3 years after the first description of ARDS was made [12], Mead et al. developed the conceptual basis for VILI from the analysis of the mechanical properties of the lungs using a theoretical model of lung elasticity [13]. They suggested that the forces acting on lung parenchyma can be actually much greater than those applied to the airway, and theorized that the pressure t
%U http://www.annalsofintensivecare.com/content/1/1/28