%0 Journal Article
%T Using hospital discharge data to identify incident pregnancy-associated cancers: a validation study
%A Yuen Yi Lee
%A Christine L Roberts
%A Jane Young
%A Timothy Dobbins
%J BMC Pregnancy and Childbirth
%D 2013
%I BioMed Central
%R 10.1186/1471-2393-13-37
%X Birth data from 2001--2008, comprised 470,277 women with 679,736 maternities, were linked to cancer registry and hospitalisation records to identify newly diagnosed cancers during pregnancy or within 12 months of delivery. Two hospital-identified cancer groups were examined; "index cancer hospitalisation" -- first cancer admission per woman per pregnancy and "all cancer hospitalisations" --the total number of hospitalisations with a cancer diagnosis and women could have multiple hospitalisations during pregnancy. The latter replicates a scenario where identification of individuals is not possible and hospitalisations are used as the unit of analysis.The incidence of pregnancy-associated cancer (according to cancer registry) was 145.4/100,000 maternities. Incidence of cancer was substantially over-estimated when using hospitalisations as the unit of analysis (incidence rate ratio, IRR 1.7) and under-estimated when using the individual (IRR 0.8). Overall, the sensitivity of "index cancer hospitalisation" was 60.4%, positive predictive value (PPV) 77.7%, specificity and negative predictive value both 100%. Melanoma ascertainment was only 36.1% and breast cancer 62.9%. For other common cancers sensitivities ranged from 72.1% to 78.6% and PPVs 56.4% to 87.3%.Although hospital data provide another timely source of cancer identification, the validity is insufficient to obtain cancer incidence estimates for the obstetric population.
%U http://www.biomedcentral.com/1471-2393/13/37/abstract