%0 Journal Article
%T Activation of dorsolateral prefrontal cortex in a dual neuropsychological screening test: An fMRI approach
%A Atsumichi Tachibana
%A J Adam Noah
%A Shaw Bronner
%A Yumie Ono
%A Yoshiyuki Hirano
%A Masami Niwa
%A Kazuko Watanabe
%A Minoru Onozuka
%J Behavioral and Brain Functions
%D 2012
%I BioMed Central
%R 10.1186/1744-9081-8-26
%X We used functional magnetic resonance imaging (fMRI) to evaluate changes in the blood oxygenation level-dependent (BOLD) signal in young healthy adults during performance of a computerized KPT dual task (comprised of reading comprehension and picking out vowels) and compared it to its single task components (reading or vowel pick-out alone).Behavioral performance of the KPT degraded compared to its single task components. Performance of the KPT markedly increased BOLD signal intensity in the PFC, and also activated sensorimotor, parietal association, and visual cortex areas. In conjunction analyses, bilateral BOLD signal in the dorsolateral PFC (Brodmann's areas 45, 46) was present only in the KPT.Our results support the central bottleneck theory and suggest that the dorsolateral PFC is an important mediator of neural activity for both short-term storage and executive processes. Quantitative evaluation of the KPT with fMRI in healthy adults is the first step towards understanding the effects of aging or cognitive impairment on KPT performance.
%K Executive function
%K Neuropsychological test
%K Working memory
%U http://www.behavioralandbrainfunctions.com/content/8/1/26/abstract