%0 Journal Article
%T The effects of exercise on C-reactive protein, insulin, leptin and some cardiometabolic risk factors in Egyptian children with or without metabolic syndrome
%A Nashwa Kamal
%A Merhan Ragy
%J Diabetology & Metabolic Syndrome
%D 2012
%I BioMed Central
%R 10.1186/1758-5996-4-27
%X The study covered 49 normal children (control), 32 obese children without metabolic syndrome and 12 obese children with metabolic syndrome. We examined the influence of exercise (3 times/week) for 12£¿weeks on the levels of serum CRP, leptin, insulin, homeostatic model assessment insulin resistance (HOMA-IR), triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) in all groups.There were significant correlations between HOMA-IR and the individual components of the metabolic syndrome. After 12£¿weeks of exercise, both of the obese children groups, with and without metabolic syndrome, showed reduced body weight, body mass index (BMI), and CRP level, and increased HDL-C level. The percentage of metabolic syndrome decreased from 12.9% before the exercise training to 7.5% after training. Also, there was a significant reduction in BMI (from 47.3 to 32.6%), in systolic blood pressure (from 18.3 to 15.1%) and in HDL-C level (from 18.3 to 9.7%).Overweight children have multiple risk factors associated with the metabolic syndrome. 12-week exercise may have a positive effect on reducing risk factors for the metabolic syndrome.Metabolic syndrome is a cluster of cardiovascular disease risk factors that include glucose intolerance, hypertension, elevated TG, low HDL-C, and obesity [1]. This clustering has been shown to occur not only in adults but also in adolescents [2]. Although the metabolic syndrome is particularly important in adults, the pathological processes and risk factors have been shown to begin during childhood [3].This syndrome continues to increase in both developed and developing countries, and has already become a major threat to the global public health [4].The prevalence of the metabolic syndrome in the children and the adolescents is relatively low; about 4% [5]. When compared to the adult population (24%), except amongst the overweight and obese adolescents where the prevalence o
%K Metabolic syndrome
%K Exercise
%K Children
%K Cardiometabolic risk factor
%K C-reactive protein and insulin
%U http://www.dmsjournal.com/content/4/1/27