%0 Journal Article
%T Atypical florid vascular proliferation in appendix: a diagnostic dilemma
%A Mi Jin Gu
%A Joon Hyuk Choi
%A So Hyun Kim
%J Diagnostic Pathology
%D 2013
%I BioMed Central
%R 10.1186/1746-1596-8-12
%X The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1386921325843104 webciteVascular proliferative lesions occurring in the gastrointestinal tract include tumors and tumor-like lesions of the vessels. With the exception of angiodysplasia, vascular abnormalities of the gastrointestinal tract are uncommon [1]. Seven cases of florid vascular proliferations occurring in the intestinal tract have been reported in English literature [1-3]. All reported cases were associated with intussusception or mucosal prolapse and showed microscopic features that overlap with those of angiosarcoma. Florid vascular proliferations are thought to be a secondary response to repeated mucosal trauma and ischemia and differential diagnosis from angiosarcoma is necessary [1]. We herein report on a challenging case showing unusual microscopic findings of the appendix.A 41-year old male presented with melena. He had no other symptoms, such as migratory pain, right lower quadrant abdominal tenderness with guarding, or leukocytosis. Colonoscopy showed non-specific findings, except for adhesioned blood clots in the appendiceal orifice. He underwent laparoscopic appendectomy. No characteristic features were observed on the external surface. Cut sections showed a tiny polypoid mucosa with easy contact bleeding and the appendiceal lumen was filled with blood. Microscopically, inflammatory cells infiltration, diverticulum, parasite, and fecalith were not observed. An exophytic polypoid mass with extensive surface ulceration was observed. The superficial portion of the polyp showed pyogenic granuloma-like features and the deeper portion was composed of vaguely lobulated proliferation of closely packed small capillary-sized vessels and showed infiltrative growth and extension into muscularis propria (Figure 1). Endothelial cells had round to ovoid nuclei and showed minimal nuclear atypia without multi-layering. Mitotic figures were observed infrequently
%K Blood vessel
%K Proliferation
%K Atypical
%K Appendix
%U http://www.diagnosticpathology.org/content/8/1/12