%0 Journal Article
%T In vitro corrosion of ZEK100 plates in Hank's Balanced Salt Solution
%A Hazibullah Waizy
%A Andreas Weizbauer
%A Christian Modrejewski
%A Frank Witte
%A Henning Windhagen
%A Arne Lucas
%A Marc Kieke
%A Berend Denkena
%A Peter Behrens
%A Andrea Meyer-Lindenberg
%A Friedrich-Wilhelm Bach
%A Fritz Thorey
%J BioMedical Engineering OnLine
%D 2012
%I BioMed Central
%R 10.1186/1475-925x-11-12
%X ZEK100 plates were examined in this in vitro study with Hank's Balanced Salt Solution under physiological conditions with a constant laminar flow rate. After 14, 28 and 42 days of immersion the ZEK100 plates were mechanically tested via four point bending test. The surfaces of the immersed specimens were characterized by SEM, EDX and XRD.The four point bending test displayed an increased bending strength after 6 weeks immersion compared to the 2 week group and 4 week group. The characterization of the surface revealed the presence of high amounts of O, P and Ca on the surface and small Mg content. This indicates the precipitation of calcium phosphates with low solubility on the surface of the ZEK100 plates.The results of the present in vitro study indicate that ZEK100 is a potential candidate for degradable orthopedic implants. Further investigations are needed to examine the degradation behavior.The first published application of a plate for fracture fixation was 1886 by Carl Hansmann [1]. It was not until the beginning of the 20th century when plates as osteosynthesis systems was spread due to the works of William Arbuthnot Lane and Albin Lambotte. In 1907 Lane, a British surgeon, introduced perforated steel plates for use in internal fixation [2]. Lambotte was one of the first to apply pure magnesium plates in a clinical case to stabilize a fracture in a young man. After implantation he observed extensive subcutaneous gas cavities and local swelling caused by rapid degradation [3].In recent years, new innovative magnesium alloys are being intensively investigated as potential resorbable materials with appropriate mechanical and corrosion properties. Particularly in orthopedic research magnesium is interesting because of its mechanical properties close to those of natural bone, the prevention of both stress shielding and removal of the implant after surgery [4]. Orthopedic implants need to provide an initial fixation and a predictable, gradually degradation adapte
%K Magnesium alloy
%K Corrosion
%K Plates
%K in vitro study
%U http://www.biomedical-engineering-online.com/content/11/1/12