%0 Journal Article
%T Chiral Separation of Basic and Zwitterionic Drugs by Highly Sulfated Cyclodextrins Using Short-End Injection Capillary Electrophoresis Highly Sulfated Cyclodextrins Using Short-End Injection Capillary Electrophoresis
%A Majid Zandkarimi
%A Alireza Shafaati
%A Sayyed Mohsen Foroutan
%J Iranian Journal of Pharmaceutical Research
%D 2008
%I School of Pharmacy, Shahid Beheshti University of Medical Sciences
%X Due to high resolution power of sulfated cyclodextrins (HS-CDs), utilization of these selectors for chiral resolution of 7 basic and 2 zwitterionic drugs have been examined. Experiments were performed on a HP3DCE instrument equipped with an on-column diode array UV absorbance detector. Fused silica capillaries with an inner diameter of 50 ¦Ìm, an outer diameter of 365 ¦Ìm, and a total length of 45.5 cm (8.5 cm to the detector) were used. Capillaries were rinsed with PEO once daily. To reduce analysis time, short-end injection technique was applied. The electrophoretic conditions for the stereoselective analysis of drugs were in the carrier mode with 25 mM sodium phosphate buffer containing 1.25% w/v of each HS-CD at pH 2.5 with an applied voltage of +15 kV. At these conditions, rapid enantioresolution(¡Ü3.9 min) of all drugs were achieved
%K Chiral
%K Capillary electrophoresis
%K Highly sulfated cyclodextrins
%K Short-end injection
%K Basic drugs
%K Zwitterionic drugs
%U http://www.ijpr-online.com/docs/20084/IJPR603.pdf