%0 Journal Article
%T Electrochemical determination of an antitumour platinum(IV) complex: trans-[PtCl2(OH)2(dimethylamine)(isopro-pylamine)]. Application to biological samples
%A CARMEN S. HERNANDEZ DOM¨ªNGUEZ
%A PEDRO HERN¨¢NDEZ
%J Journal of Electrochemical Science and Engineering
%D 2013
%I 
%R 10.5599/jese.2013.0031
%X A differential pulse voltammetry (DPV) method has been applied for the first time for determination of trans-Pt[Cl2(OH)2(dimethylamine)(isopropylamine)]. To this end, all chemical and instrumental variables affecting the determination of trans-Pt[Cl2(OH)2(dimethylamine)(isopropylamine)] were optimized. From studies of the mechanisms governing the electrochemical response of trans-Pt[Cl2(OH)2(dimethylamine)(isopropylamine)], it was concluded that it is an electrochemically irreversible system with a reduc-tion under diffusion control, with a reduction potential of -425 mV. Under optimal conditions, the variation in the analytical signal (Ip) with trans-Pt[Cl2(OH)2(dimethylamine)(isopropylamine)] concentration is linear in the 0.8 ¦Ìg mL-1 to 20 ¦Ìg mL-1 range, with an LOD of 97 ng mL-1 and a LOQ of 323 ng mL-1, RSD = 1.58 % and Er = 0.83 %. The optimized method was applied to the determination of trans-Pt[Cl2(OH)2(di-methylamine)(isopropylamine)] in biological fluids, human urine and synthetic urine
%K Trans-Pt[Cl2(OH)2(dimethylamine)(isopropylamine)]
%K differential pulse voltammetry
%K biological fluids
%K human urine
%U http://www.jese-online.org/Articles/Vol_03/No_2/Pdf/jESE_Vol3_No2_p81-89_2013.pdf