%0 Journal Article
%T Co-Inheritance of Sickle Cell Trait and Thalassemia Mutations in South Central Iran
%A N Saleh-Gohari
%A M Mohammadi-Anaie
%J Iranian Journal of Public Health
%D 2012
%I Tehran University of Medical Sciences
%X Background: We aimed to determine the incidence of co-inheritance as well as interaction of sickle cell trait (SCT)and ¦Áthal/¦Âthal mutations in south and south central of Iran.Method: We employed a PCR and restriction fragment length polymorphism techniques to confirm diagnosis of sickle cell trait. All subjects were screened for any ¦Á/¦Â ¨Cthalassemia mutations using a gap-polymerase chain reaction and amplification refractory mutations system.Results: Our results showed combination of sickle cell trait and ¦Â-globin mutation results in a severe clinical course of similar to sickle cell disease, while coinheritance of ¦Á-globin gene defects usually modulates the clinical course. A coexistence of sickle cell trait and ¦Á-globin gene mutation was the frequent genotype in overall samples (57. 5%).Conclusion: Sickle cell trait mainly co-inherits with ¦Á-globin gene mutation in the south and south central region of Iran. This combination modulates hematological indices and interferes with the SCT diagnosis.
%K Sickle Cell Trait
%K ¦Â-Thalassemia
%K A-Thalassemia
%K Iran
%U http://journals.tums.ac.ir/upload_files/pdf/_/22216.pdf