%0 Journal Article
%T Performance of conventional pigs and G ttingen miniature pigs in a spatial holeboard task: effects of the putative muscarinic cognition impairer Biperiden
%A Gieling Elise
%A Wehkamp Welmoed
%A Willigenburg Remco
%A Nordquist Rebecca E
%J Behavioral and Brain Functions
%D 2013
%I BioMed Central
%R 10.1186/1744-9081-9-4
%X Background The pig is emerging as a model species that bridges the gap between rodents and humans in research. In particular, the miniature pig (referred to hereafter as the minipig) is increasingly being used as non-rodent species in pharmacological and toxicological studies. However, there is as yet a lack of validated behavioral tests for pigs, although there is evidence that the spatial holeboard task can be used to assess the working and reference memory of pigs. In the present study, we compared the learning performance of commercial pigs and G ttingen minipigs in a holeboard task. Methods Biperiden, a muscarinic M1 receptor blocker, is used to induce impairments in cognitive function in animal research. The two groups of pigs were treated orally with increasing doses of biperiden (0.05 ¨C 20 mg.kg-1) after they had reached asymptotic performance in the holeboard task. Results Both the conventional pigs and the G ttingen minipigs learned the holeboard task, reaching nearly errorless asymptotic working and reference memory performance within approximately 100 acquisition trials. Biperiden treatment affected reference, but not working, memory, increasing trial duration and the latency to first hole visit at doses ¡Ý 5 mg.kg-1. Conclusion Both pig breeds learned the holeboard task and had a comparable performance. Biperiden had only a minor effect on holeboard performance overall, and mainly on reference memory performance. The effectiveness needs to be evaluated further before definitive conclusions can be drawn about the ability of this potential cognition impairer in pigs.
%K Working memory
%K Reference memory
%K Animal model
%K Holeboard task
%K Spatial learning task
%K Biperiden
%U http://www.behavioralandbrainfunctions.com/content/9/1/4