%0 Journal Article
%T SiO2/H2SO4: An Efficient Catalytic System for Solvent-free 1, 5-benzodiazepines Synthesis
%A Mohammad Shushizadeh
%A Narges Dalband
%J Jundishapur Journal of Natural Pharmaceutical Products
%D 2012
%I Ahvaz Jundishapur University of Medical Sciences
%X Background: 1, 5-Benzodiazepines have been investigated extensively by organic chemists due to their medicinal and pharmacological properties. These compounds are synthesized by condensation of o-phenylenediamines with carbonyl compounds in the presence of acid catalysts..Objectives: During our studies on the application of silica resin with acid functional moieties, we found that SiO2/H2SO4 mixture is a simple and efficient catalyst for this method under microwave irradiation..Materials and Methods: The reaction was carried out simply by grinding SiO2/H2SO4 mixture with o-phenylenediamine, and ketone in the mortar; then the mixture was poured out into a sealed flask. Subsequently, it was irradiated in a microwave oven..Results: In this method a series of cyclic and acyclic ketones underwent above conversion to form corresponding 1, 5-benzodiazepines..Conclusions: In conclusion, this method is a simple, rapid, and high yielding reaction (78¨C95%).
%K Sulfuric acid
%K Ketones1
%K 2-diaminobenzene
%K Microwave
%K Radiotherapy
%U http://jjnpp.com/?page=article&article_id=3624