%0 Journal Article
%T Novel thermosensitive poly (N-isopropylacrylamide-co-vinylpyrrolidone-co-methacrylic acid) nanosystems for delivery of natural products
%A Omid Mashinchian
%A Roya Salehi
%A Gholamreza Dehghan
%A Ayoub Aganejad
%J International Journal of Drug Delivery
%D 2011
%I Advanced Research Journals
%X The purpose of this research was to synthesize polymer based smart nanosystems for delivery of important bioactive natural products such as sesquiterpene coumarin derivatives of ferula szowitsiana, farnesiferol C as a potent anticancer. To this aim, polymeric micelles were prepared using N-isopropylacrylamide (NIPAAM), vinyl pyrrolidone (VP) and methacrylate (MAA) as monomers which were cross-linked with N, N-methylene bis-acrylamide (MBA). The molar ratio of the PNIPAAm: VP: MAA group was 75.7:9.5:14.8. These micelles were further characterized upon their physicochemical properties using particle size analyzer, FT-IR, H-/C-NMR, HPLC. Particle size analyzer resulted in ~500 nm micelles with ~95% drug entrapments. Drug release from the polymeric micelles after 300 hours at 37ˇăC and 40ˇăC were 60 and 98 %, respectively. Upon these findings, it is proposed that the P (N-isopropylacrylamide-co-Methacrylic acid-co-Vinylpyrrolidone) micelles may be considered as thermosensitive delivery nanosystem. Keywords: N-isopropylacrylamide; Thermosensitive; Nanoparticles; Farnesiferol C; Amphiphilic polymers.
%K N-isopropylacrylamide
%K Thermosensitive
%K Nanoparticles
%K Farnesiferol C
%K Amphiphilic polymers.
%U http://www.arjournals.org/index.php/ijdd/article/view/53