%0 Journal Article
%T Design and evaluation of taste masked chewable dispersible tablet of lamotrigine by melt granulation
%A Pankaj P. Amrutkar
%A Sanjay B. Patil
%A Abhijeet N. Todarwal
%A Manoj A. Wagh
%J International Journal of Drug Delivery
%D 2011
%I Advanced Research Journals
%X Lamotrigine, an antiepileptic drug (AED) of the phenyltriazine class, is chemically unrelated to existing antiepileptic drugs. Lamotrigine is also used in the treatment of depression and bipolar disorder. But it is a bitter drug and slightly soluble in water. Thus, in the work under taken, an attempt was made to mask the taste and to formulate into a chewable dispersible tablet by complexation with Precirol ATO-05, which also acts as taste masking agent. Since, these tablets can be swallowed in the form of dispersion; it is suitable dosage form for paediatric and geriatric patients. Drug-Precirol ATO-05 was prepared in drug to Precirol ATO-05 ratio of 1:2, 1:1.5, 1:1, 1:0.5. The prepared tablets were evaluated for general appearance, content uniformity, hardness, friability, taste evaluation, mouth feel, in vitro disintegration time, and in vitro dissolution studies. Tablets with Precirol ATO-05 have shown good disintegrating features, also, the dispersion not showing any bitter taste, indicate the capability of Precirol ATO-05 used, both as taste masking agents. Almost more than 90 percent of drug was released from the formulation within 1 h. Further formulations were subjected to stability testing for 3 months at temperatures 25¡À5oC/60¡À5%RH; 30¡À5oC/65¡À5%RH and 40¡À5oC/75¡À5%RH. Tablets have shown no appreciable changes with respect to taste, disintegration, and dissolution profiles. Keywords: Lamotrigine; Melt granulation; Precirol; Taste masking; Chewable dispersible tablets.
%K Lamotrigine
%K Melt granulation
%K Precirol
%K Taste masking
%K Chewable dispersible tablets.
%U http://www.arjournals.org/index.php/ijdd/article/view/42