%0 Journal Article
%T Efficient Cu-catalyzed base-free C¨CS coupling under conventional and microwave heating. A simple access to S-heterocycles and sulfides
%A Silvia M. Soria-Castro
%A Alicia B. Pe£¿¨¦£¿ory
%J Beilstein Journal of Organic Chemistry
%D 2013
%I 
%R 10.3762/bjoc.9.50
%X S-aryl thioacetates can be prepared by reaction of inexpensive potassium thioacetate with both electron-rich and electron-poor aryl iodides under a base-free copper/ligand catalytic system. CuI as copper source affords S-aryl thioacetates in good to excellent yields, by using 1,10-phenanthroline as a ligand in toluene at 100 ¡ãC after 24 h. Under microwave irradiation the time was drastically reduced to 2 h. Both procedures are simple and involve a low-cost catalytic system. This methodology was also applied to the ¡°one-pot¡± synthesis of target heterocycles, such as 3H-benzo[c][1,2]dithiol-3-one and 2-methylbenzothiazole, alkyl aryl sulfides, diaryl disulfides and asymmetric diaryl sulfides in good yields.
%K catalysis
%K copper
%K cross-coupling
%K potassium thioacetate
%K sulfur heterocycles
%U http://dx.doi.org/10.3762/bjoc.9.50