%0 Journal Article
%T Microwave-assisted three-component domino reaction: Synthesis of indolodiazepinotriazoles
%A Rajesh K. Arigela
%A Sudhir K. Sharma
%A Brijesh Kumar
%A Bijoy Kundu
%J Beilstein Journal of Organic Chemistry
%D 2013
%I 
%R 10.3762/bjoc.9.41
%X A microwave-assisted three-component protocol involving N-1 alkylation of 2-alkynylindoles with epichlorohydrin, ring opening of the epoxide with sodium azide, and an intramolecular Huisgen azide¨Cinternal alkyne 1,3-dipolar cycloaddition domino sequence has been described. The efficacy of the methodology has been demonstrated by treating various 2-alkynylindoles (aromatic/aliphatic) with epichlorohydrin and sodium azide furnishing annulated tetracyclic indolodiazepinotriazoles in satisfactory yields.
%K 2-alkynylindoles
%K azides
%K 1
%K 3-dipolar cycloaddition
%K domino reaction
%K indolodiazepinotriazoles
%U http://dx.doi.org/10.3762/bjoc.9.41