%0 Journal Article
%T End-labeled amino terminated monotelechelic glycopolymers generated by ROMP and Cu(I)-catalyzed azide¨Calkyne cycloaddition
%A Ronald Okoth
%A Amit Basu
%J Beilstein Journal of Organic Chemistry
%D 2013
%I 
%R 10.3762/bjoc.9.66
%X Functionalizable monotelechelic polymers are useful materials for chemical biology and materials science. We report here the synthesis of a capping agent that can be used to terminate polymers prepared by ring-opening metathesis polymerization of norbornenes bearing an activated ester. The terminating agent is a cis-butene derivative bearing a Teoc (2-trimethylsilylethyl carbamate) protected primary amine. Post-polymerization modification of the polymer was accomplished by amidation with an azido-amine linker followed by Cu(I)-catalyzed azide¨Calkyne cycloaddition with propargyl sugars. Subsequent Teoc deprotection and conjugation with pyrenyl isothiocyanates afforded well-defined end-labeled glycopolymers.
%K capping agent
%K carbohydrate
%K glycan
%K olefin metathesis
%K triazole
%U http://dx.doi.org/10.3762/bjoc.9.66