%0 Journal Article
%T Inter- and intramolecular enantioselective carbolithiation reactions
%A Asier G¨®mez-SanJuan
%A Nuria Sotomayor
%A Esther Lete
%J Beilstein Journal of Organic Chemistry
%D 2013
%I 
%R 10.3762/bjoc.9.36
%X In this review we summarize recent developments in inter- and intramolecular enantioselective carbolithiation reactions carried out in the presence of a chiral ligand for lithium, such as ( )-sparteine, to promote facial selection on a C=C bond. This is an attractive approach for the construction of new carbon¨Ccarbon bonds in an asymmetric fashion, with the possibility of introducing further functionalization on the molecule by trapping the reactive organolithium intermediates with electrophiles.
%K alkenes
%K asymmetric synthesis
%K carbolithiation
%K carbometallation
%K enantioselectivity
%K lithium
%U http://dx.doi.org/10.3762/bjoc.9.36