%0 Journal Article
%T A peptidic hydrogel that may behave as a ˇ°Trojan Horseˇ±
%A Nicola Castellucci
%A Giorgio Sartor
%A Natalia Calonghi
%A Carola Parolin
%J Beilstein Journal of Organic Chemistry
%D 2013
%I 
%R 10.3762/bjoc.9.44
%X A physical hydrogel prepared with the low-molecular-weight hydrogelator (LMWHG) CH2(C3H6CO-L-Phe-D-Oxd-OH)2 and water/ethanol mixture was applied as a potential ˇ°Trojan Horseˇ± carrier into cells. By SEM and XRD analysis we could demonstrate that a fibrous structure is present in the xerogel, making a complex network. The gelator is derived from ¦Á-amino acids (Thr, Phe) and a fatty acid (azelaic acid) and is biocompatible: it was dosed to IGROV-1 cells, which internalized it, without significantly affecting the cell proliferation. To check the internalization process by confocal microscopy, fluorescent hydrogels were prepared, introducing the fluorescent dansyl moiety into the mixture.
%K amino acids
%K confocal microscopy
%K controlled release
%K hydrogel
%K low molecular weight hydrogelator
%U http://dx.doi.org/10.3762/bjoc.9.44