%0 Journal Article
%T Sinthetic study of some beta-aminoketones using thiazolidine as catalyst
%A ¨¦rica Cristina da Silva
%A Ana Claudia da S. Lima
%A Paula Vanessa de S. Rizzo
%A Andrelson W. Rinaldi
%J Orbital : the Electronic Journal of Chemistry
%D 2012
%I Universidade Federal de Mato Grosso do Sul
%X Mannich reaction is one of the most widely used in organic chemistry. In this reaction, there is a insertion of a aminomethyl group on the ¦Á position to the carbonyl group. Such reaction has numerous applying in organic chemistry in the synthesis of product with biological interest, such as analgesics and antibiotics. To form the Mannich¡¯s bases a catalyst is needed and, with this purpose, the thiazolidines were used. Thiazolidines are cyclic compounds of five members which contain on the position 1 the sulphur atom and on the position 3 the nitrogen one. All the reactions were carried out at room temperature involving cyclopetanone, formaldehyde and various imines (aniline, p-chloroaniline and p-toluidine) (Scheme 1). The products of interest were satisfactorily obtained and their structures were confirmed through spectrometric methodologies.
%K Mannich reactions
%K thiazolidines
%K theoretical calculations
%U http://www.orbital.ufms.br/index.php/Chemistry/article/view/378