%0 Journal Article
%T Synthesis of 2-(4-Aminomethyl-1H-1,2,3-Triazole-1-yl)-1,4-Naphthoquinone Derivatives S¨ªntese de derivados de 2-(4-aminometil-1H-1,2,3-triazol-1-il)-1,4-naftoquinona
%A Wagner O. Valen£¿a
%A Mauro G. da Silva
%A Celso A. Camara
%A Ronaldo N. de Oliveira
%J Orbital : the Electronic Journal of Chemistry
%D 2012
%I Universidade Federal de Mato Grosso do Sul
%X In this work, were synthesized 18 new compounds based on 1H-1,2,3-triazole-1,4-naphthoquinones via Cu-AAC (Cu-catalyzed Azide Alkyne Cycloaddition) reaction. The compounds (2-7)(a-c) were obtained in moderate-to-good yields (43-99%). Two methodologies were employed to obtain 2-(4-aminomethyl-1H-1,2,3-triazol-1-yl)-1,4-naphthoquinone derivatives. Firstly, we using the Method A (CH3CN/CuI/r.t./20h), but some compounds presented moderate yields of 43-60%. Fortunately, when we applied the Method B (DMF/Et3N/ultrasound), were obtained yields between 78 and 92%. Neste trabalho, foram sintetizados 18 compostos novos baseados na estrutura de 1H-1,2,3-triaz¨®is-1,4-naftoquin nicos via rea  o Cu-AAC ¡°Cu-catalyzed Azide Alkyne Cycloaddition¡± (Esquema 1). Os compostos (2-7)(a-c) foram obtidos em rendimentos de moderados a bons (47-99%). Duas metodologias foram utilizadas para obter os derivados da 2-(4-aminometil-1H-1,2,3-triazol-1-il)-1,4-naftoquinona. Primeiramente, usamos o m¨¦todo A (CH3CN/CuI/t.a./20h), mas alguns compostos apresentaram moderados rendimentos de 43-60%. Felizmente, quando aplicamos o M¨¦todo B (DMF/Et3N/ultrassom), foram obtidos rendimentos entre 78 e 92%.
%K 1
%K 2
%K 3-triazol
%K 2-aminometil
%K 1
%K 4-naftoquinona
%K cicloadi  o
%U http://www.orbital.ufms.br/index.php/Chemistry/article/view/373